Ketamine Therapy


Breaking Stigma

Reviving Hope with Ketamine Therapy

The Lime Infusion Lounge and Wellness Homes of Chicago together seek to destigmatize Ketamine for legitimate use!

Ketamine as a therapy has been stigmatized in the medical community because of its potential for abuse. The Lime Infusion Lounge and Wellness Homes of Chicago recognizes that this stigma associated with the use of Ketamine for legitimate reasons is no different from the stigma and bias that have plagued people living with HIV, AIDS, and obesity. This stigma and bias prevent patients from receiving care that could potentially relieve them from life-long suffering from pain and depression. We understand, and we welcome you to make an appointment to learn more about our revolutionized Ketamine Therapy Program.

Treatment Options


IV Ketamine Infusions

Racemic Ketamine is given as an infusion into the bloodstream. This is sometimes called intravenous, or IV Ketamine. It is a mixture of two mirror-image molecules: “R” and “S” ketamine. While it was approved decades ago as an anesthetic by the FDA, it is used off-label to treat depression.

Nasal Ketamine Spray

Esketamine (Spravato), which the FDA approved is a fast acting, effective nasal spray treatment that uses only the “S” molecule. Esketamine can be helpful when dealing with treatment-resistant depression, and can work as a standalone treatment or complement an oral antidepressant.

Mental health professionals tend to prescribe esketamine nasal spray for its speed and effectiveness, as it can tackle various symptoms of depression in a matter of minutes. 

Ketamine for Depression



Major depressive illness is a debilitating condition which is a matter of concern worldwide affecting millions of people causing a considerable burden on health and socioeconomic status. As per the World Health Organization, depression is third among global disease burden. Ketamine Therapy is just as effective as electroconvulsive therapy (ECT) for the treatment of non-psychotic, treatment-resistant depression.

How Ketamine helps to treat depression

Researchers are still trying to identify the exact mechanism of actions. However, it is thought that the target for ketamine is NMDA receptors in the brain. By binding to these receptors, ketamine increases the amount of a neurotransmitter called glutamate in the spaces between neurons. Glutamate then activates connections in another receptor, called the AMPA receptor. Together, the initial blockade of NMDA receptors and activation of AMPA receptors lead to the release of other molecules that help neurons communicate with each other along new pathways. Known as synaptogenesis, this process likely affects mood, thought patterns, and cognition.

Ketamine for Chronic Pain


Chronic Pain

Chronic pain affects 20% of the population worldwide, and many patients experience its detrimental effects on their quality of life and mental health. Unlike neuropathic, musculoskeletal, postoperative pain, and cancer pain, chronic primary pain cannot be explained by an underlying disease or condition, making its treatment arduous. Now there is hope!

How Ketamine helps to treat Chronic Pain

Ketamine is an NMDA (short for N-methyl-D-aspartate) antagonist that also acts on opioid receptors. Ketamine provides an analgesic effect for patients suffering from chronic pain by occupying brain and spinal cord mu-opioid receptors. When the NMDA receptor is activated by glutamate, the channel opens to allow calcium to flow inside the neuron; in this open state ketamine enters and binds inside the channel and blocks subsequent calcium entry and NMDA receptor function.

Getting Started

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